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Updated: Jul 20, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy
M H Frost1, D J Schaid, T A Sellers
1Division of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Prophylactic mastectomy significantly reduces breast cancer concerns for most women, with generally positive long-term psychological and social outcomes. However, potential negative effects and the procedure's irreversibility require careful consideration.
Area of Science:
- Oncology
- Preventive Medicine
- Psychology
Background:
- Prophylactic mastectomy is a surgical option to reduce breast cancer risk.
- Concerns exist regarding potential negative psychological effects post-procedure.
- Limited data exist on long-term satisfaction and psychosocial function after prophylactic mastectomy.
Purpose of the Study:
- To assess long-term patient satisfaction following prophylactic mastectomy.
- To evaluate the long-term psychological and social functioning of women who underwent prophylactic mastectomy.
Main Methods:
- A descriptive study surveyed 572 women who underwent bilateral prophylactic mastectomy between 1960 and 1993.
- The study focused on women with a family history of breast cancer.
- Data collected via questionnaire assessed satisfaction and psychosocial outcomes.
Main Results:
- Most women (70%) reported satisfaction with prophylactic mastectomy.
- A significant majority (74%) experienced reduced emotional concern about developing breast cancer.
- While most reported stable or improved emotional stability, self-esteem, and relationships, some experienced negative effects on body image and other psychosocial variables.
Conclusions:
- Prophylactic mastectomy can lead to decreased breast cancer anxiety and favorable psychosocial outcomes.
- The irreversibility of the procedure and potential adverse effects must be weighed against benefits.
- Careful consideration of reconstructive surgery and individual patient factors is crucial.
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