Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Helicases and aging.

J Nakura1, L Ye, A Morishima

  • 1Department of Geriatric Medicine, School of Medicine, Ehime University, Japan. nakura@m.ehime-u.ac.jp

Cellular and Molecular Life Sciences : CMLS
|July 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Successful treatment of COVID-19 with colchicine in a kidney transplant recipient.

QJM : monthly journal of the Association of Physicians·2020
Same author

Creatinine to Cystatin C Ratio as a Marker of Bone Property in Older Adults: The J-SHIPP Study.

The journal of nutrition, health & aging·2020
Same author

[Prognostic value of total cholesterol content of erythrocyte membranes in patients with acute coronary syndrome].

Zhonghua xin xue guan bing za zhi·2019
Same author

Anti-tumor effects of lidocaine on human gastric cancer cells in vitro.

Bratislavske lekarske listy·2019
Same author

Heterogeneous health profiles and healthcare utilization of the middle-aged and elderly with multiple health insurance schemes in China.

Public health·2019
Same author

[An analysis on incidence of HIV-1 epidemics among men who have sex with men in Sichuan Province during 2011-2015].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2019
Same journal

Elektra-Qki and Alien-Wt1 lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

SHIP1 is required for T cell surveillance of occult malignancies.

Cellular and molecular life sciences : CMLS·2026
Same journal

Reply to: Commentary on "The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of MAPK signaling pathway".

Cellular and molecular life sciences : CMLS·2026
Same journal

The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Investigating rare genetic disorders linked to aging reveals that protein helicase dysfunction may drive age-related conditions and normal aging processes. This suggests helicase function is crucial for cellular and organismal health.

Area of Science:

  • Genetics
  • Molecular Biology
  • Gerontology

Background:

  • Monogenic hereditary disorders with age-related phenotypes offer insights into aging mechanisms.
  • Seven specific human disorders are linked to aberrations in five proteins possessing conserved helicase motifs.

Purpose of the Study:

  • To explore the role of helicase function decline in age-related phenotypes of specific genetic disorders.
  • To investigate the potential connection between helicase aberrations and the universal aging process.

Main Methods:

  • Review and analysis of existing studies on seven human genetic disorders with age-related phenotypes.
  • Examination of the role of helicase motifs and their conservation in identified proteins.

Main Results:

Related Experiment Videos

  • Aberrations in proteins with conserved helicase motifs are implicated in seven distinct human disorders exhibiting age-related phenotypes.
  • A decline in helicase function is suggested to underlie both the specific disorder phenotypes and general aging.

Conclusions:

  • Helicase dysfunction is a potential key factor in age-related phenotypes observed in specific genetic disorders.
  • Understanding helicase aberrations in these disorders may illuminate fundamental mechanisms of aging.