Related Experiment Video
Updated: Aug 1, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
[Kaposi sarcoma associated with HIV infection]
A M Miranda1, M H Gomes, R Marques
1Serviço de Doenças Infecciosas, Hospital S. João, Faculdade de Medicina do Porto.
Acta Medica Portuguesa
|July 13, 2000
Summary
Kaposi's sarcoma is a common cancer in patients with acquired immunodeficiency syndrome (AIDS). This study reviews 45 cases, noting its frequent occurrence as an initial AIDS symptom, predominantly in males.
Area of Science:
- Oncology
- Infectious Diseases
- Epidemiology
Context:
- Kaposi's sarcoma is the most frequent neoplasm in individuals with acquired immunodeficiency syndrome (AIDS).
- This study analyzed 45 cases of Kaposi's sarcoma diagnosed over a 12-year period in 552 AIDS patients.
- The research reviews the epidemiological and clinical characteristics of Kaposi's sarcoma in this population.
Purpose:
- To review the epidemiological and clinical aspects of Kaposi's sarcoma in patients with acquired immunodeficiency syndrome (AIDS).
- To understand the presentation, risk factors, and outcomes of Kaposi's sarcoma in the context of AIDS.
Summary:
- The study identified 45 cases (8%) of Kaposi's sarcoma among 552 AIDS patients over 12 years.
- The disease predominantly affected males and homosexual individuals, often presenting as the first manifestation of AIDS (67% of cases).
- Skin/oral lesions were most common, with 29% experiencing visceral involvement. Most patients had opportunistic diseases and severe immunosuppression.
Impact:
- Kaposi's sarcoma was the primary cause of death in 5 patients, and opportunistic infections caused death in 30.
- Advances in antiretroviral therapy, combined with chemotherapy, show promise in reducing Kaposi's sarcoma morbidity in AIDS patients.
- This research highlights the significant burden of Kaposi's sarcoma in AIDS and the potential benefits of integrated treatment approaches.
Related Concept Videos
01:10Retrovirus Life Cycles
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...