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Antihistamines and epithelial cells.

F M Graziano1, E B Cook, J L Stahl

  • 1University of Wisconsin, Madison 53792-3244, USA.

Allergy and Asthma Proceedings
|July 13, 2000
PubMed
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Second-generation antihistamines show anti-inflammatory effects beyond allergy symptom relief. These H1-receptor antagonists may help manage airway inflammation by reducing eosinophil activity and mediator release.

Area of Science:

  • Allergy and Immunology
  • Pulmonology
  • Pharmacology

Background:

  • Antihistamines are standard for allergic rhinitis and conjunctivitis symptom relief.
  • Second-generation antihistamines are investigated for anti-inflammatory properties in airway diseases.
  • Airway epithelial cells are crucial in the development of airway diseases.

Purpose of the Study:

  • To explore the anti-inflammatory potential of second-generation antihistamines.
  • To assess their effects on inflammatory cells and mediators in allergic airway disease.
  • To evaluate their impact on airway epithelial cell activity.

Main Methods:

  • In vitro studies examining eosinophil migration and mast cell mediator release.
  • In vivo studies assessing inflammatory cell infiltration and mediator release in allergic airway models.

Related Experiment Videos

  • Studies investigating the modulation of adhesion molecule expression on airway epithelial cells.

    • Main Results:

    • Second-generation antihistamines reduced eosinophil migration and activation.
    • These agents diminished pro-inflammatory mediator release from mast cells and basophils.
    • Evidence suggests modulation of airway inflammation via effects on epithelial cells, including decreased adhesion molecule expression.

    Conclusions:

    • Second-generation H1-histamine receptor antagonists possess significant anti-inflammatory activity.
    • They show potential as safe alternatives to corticosteroids for airway inflammation.
    • These antihistamines may serve as adjunctive therapy with corticosteroids for severe airway disease.