Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise and neuroendocrine modulation of macrophage function.

J A Woods1

  • 1Department of Kinesiology, University of Illinois, Urbana, Champaign 61801, USA. Woods1@uiuc.edu

International Journal of Sports Medicine
|July 13, 2000
PubMed
Summary

Exercise influences macrophage function through neuroendocrine pathways. This review explores how hormones from the sympathetic nervous system and HPA axis regulate immune cells during physical activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism.

Experimental dermatology·2023
Same author

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice.

Gut microbes·2017
Same author

The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing.

Journal of photochemistry and photobiology. B, Biology·2015
Same author

Photodynamic therapy in dermatology: Dundee clinical and research experience.

Photodiagnosis and photodynamic therapy·2014
Same author

Porphyrin profile in four human cell lines after supplementation with 5-aminolaevulinic acid and its methyl ester.

Photodiagnosis and photodynamic therapy·2013
Same author

Plasma ropivacaine concentrations during bilateral transversus abdominis plane infusions.

British journal of anaesthesia·2013

Area of Science:

  • Immunology
  • Neuroendocrinology
  • Exercise Physiology

Background:

  • Macrophages (Mphi) are key immune cells involved in host defense.
  • Mphi function is regulated by complex cellular networks and neuroendocrine factors.
  • Stressors like exercise can modulate Mphi activity via the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis.

Purpose of the Study:

  • To review the role of neuroendocrine factors in exercise-induced changes in Mphi function.
  • To discuss Mphi cell biology and host defense roles.
  • To explore specific neuroendocrine hormones (glucocorticoids, catecholamines, growth hormone, prolactin, beta-endorphin) potentially mediating these effects.
  • To describe exercise's impact on Mphi functions.

Main Methods:

Related Experiment Videos

  • Literature review of existing research on Mphi biology, neuroendocrine regulation, and exercise physiology.
  • Synthesis of information on the interplay between the neuroendocrine system and immune cells.
  • Analysis of studies investigating exercise effects on Mphi function.

Main Results:

  • Neuroendocrine hormones significantly influence Mphi behavior and immune responses.
  • Exercise activates the SNS and HPA axis, impacting Mphi through hormonal signaling.
  • Specific hormones like glucocorticoids and catecholamines play crucial roles in modulating Mphi activity post-exercise.

Conclusions:

  • Neuroendocrine factors are critical mediators of exercise-induced alterations in Mphi function.
  • Understanding these pathways provides insights into immune system adaptation to physical stress.
  • Further research can elucidate targeted interventions for optimizing immune health through exercise and neuroendocrine modulation.