RecQ-like helicases: the DNA replication checkpoint connection.

¹Swiss Institute for Experimental Cancer Research (ISREC) Ch. des Boveresses 155, CH-1066 Epalinges/Lausanne, Switzerland.

|July 13, 2000

Summary

Eukaryotic RecQ DNA helicases maintain genome stability and ensure cell division. Deficiencies in these enzymes lead to cancer predisposition, with roles in DNA replication and S-phase checkpoints.

Related Concept Videos

You might also read

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026

Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026

Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026

Area of Science:

Genetics
Molecular Biology
Cell Biology

Background:

Eukaryotic RecQ DNA helicases are crucial for maintaining genome stability.
Deficiencies in these enzymes are linked to cancer predisposition in humans.

Purpose of the Study:

To elucidate the conserved roles of eukaryotic RecQ DNA helicases.
To understand their function in cell division and cancer etiology.
To investigate their involvement in DNA replication and S-phase checkpoints.

Main Methods:

Comparative analysis of yeast and mammalian systems.
Genetic studies to assess enzyme function.
Biochemical assays to determine helicase activity.

Main Results:

Yeast Sgs1p and human homologues (Bloom's and Werner's syndrome genes) are involved in genome stability.
These helicases function during DNA replication.
Evidence suggests a role in an S-phase-specific replication checkpoint.

Conclusions:

Eukaryotic RecQ helicases are essential for normal cell division and genome integrity.
Dysfunctional helicases contribute to cancer susceptibility.
These enzymes are key players in DNA replication and cell cycle regulation.

Related Experiment Videos

RecQ-like helicases: the DNA replication checkpoint connection.

Related Concept Videos

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Related Experiment Videos

RecQ-like helicases: the DNA replication checkpoint connection.

Related Concept Videos

Related Articles

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions: