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Creatine and creatinine metabolism.

M Wyss1, R Kaddurah-Daouk

  • 1F. Hoffmann-La Roche, Vitamins and Fine Chemicals Division, Basel, Switzerland. markus.wyss@roche.com

Physiological Reviews
|July 14, 2000
PubMed
Summary
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This review explores creatine (Cr) and creatinine metabolism, detailing their roles in health and disease. New findings link creatine kinase (CK) system dysfunction to various pathologies and highlight Cr

Area of Science:

  • Biochemistry
  • Metabolic pathways
  • Physiology

Background:

  • Creatine (Cr) and creatinine are key metabolites with crucial physiological roles.
  • The creatine kinase (CK) system is vital for cellular energy homeostasis.
  • Recent discoveries reveal new implications for Cr metabolism in health and disease.

Purpose of the Study:

  • To comprehensively review creatine and creatinine metabolism.
  • To explore the regulation of Cr biosynthesis and degradation.
  • To discuss the implications of Cr and CK system disturbances in human pathology and diagnosis.

Main Methods:

  • Literature review of existing research on creatine metabolism.
  • Analysis of enzyme and metabolite distribution across species and tissues.

Related Experiment Videos

  • Synthesis of recent findings on the role of the CK system in disease.

    • Main Results:

    • Deregulation of the CK system is associated with muscle, brain, cardiac, renal diseases, and cancer.
    • Creatine and its analogs exhibit antitumor, antiviral, and antidiabetic effects.
    • Creatine has potential therapeutic applications for tissue protection and ergogenic benefits.

    Conclusions:

    • Creatine metabolism and the CK system are integral to cellular function and disease pathogenesis.
    • Understanding these pathways offers insights into novel diagnostic and therapeutic strategies.
    • Further research is needed to fully elucidate the complex roles of creatine in human health.