High cognitive outcome in an adolescent with mut- methylmalonic acidemia

L Varvogli1, G M Repetto, S E Waisbren

  • 1Division of Genetics, Department of Medicine, Children's Hospital, Boston, Massachusetts 02115, USA.

Insights

Methylmalonic acidemia (MMA) can present with varying cognitive outcomes. Even with moderate biochemical severity and ketoacidosis, some individuals with the mut(-) form of MMA may achieve gifted intellectual status.

Area of Science:

  • Biochemistry
  • Genetics
  • Neurodevelopmental Disorders

Background:

  • Methylmalonic acidemia (MMA) is an inherited metabolic disorder.
  • The mut(-) form of MMA is typically associated with mild to moderate cognitive deficits.

Observation:

  • A longitudinal study assessed a girl with symptomatic mut(-) MMA and recurrent ketoacidosis.
  • Biochemical abnormalities were in the moderately severe range.

Findings:

  • At nearly 12 years old, she achieved a full-scale IQ of 129.
  • She scored above the 99th percentile on the National Achievement Test, indicating giftedness.

Implications:

  • The cognitive spectrum in mut(-) MMA is broader than previously documented.
  • Moderate biochemical severity and ketoacidotic episodes do not always lead to cognitive impairment.

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