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A new formulation of fenofibrate: suprabioavailable tablets
J P Guichard1, P Blouquin, Y Qing
1Laboratoires Fournier, Fontaine les Dijon, Daix, France.
Current Medical Research and Opinion
|July 14, 2000
Summary
A new suprabioavailable fenofibrate tablet formulation improves drug absorption predictability and reduces variability. This enhanced fenofibrate delivery may offer a more efficient and better-tolerated treatment option.
Area of Science:
- Pharmaceutical Technology
- Pharmacokinetics
- Drug Formulation
Background:
- Fenofibrate is a widely used lipid-lowering drug.
- Existing formulations can exhibit significant inter-subject variability in absorption.
- Food effect can influence fenofibrate bioavailability.
Purpose of the Study:
- To describe the development of a new suprabioavailable fenofibrate tablet.
- To evaluate the pharmacokinetic profile of the novel formulation.
Main Methods:
- Development of a novel tablet combining micronisation and micro-coating technologies.
- Assessment of fenofibrate dissolution and in vivo bioavailability.
Main Results:
- The new formulation demonstrates enhanced and predictable drug absorption.
- Equivalent plasma levels achieved at lower doses with reduced inter-subject variability.
- A reduced food effect was observed with the new formulation.
Conclusions:
- The suprabioavailable fenofibrate tablet offers improved pharmacokinetic properties.
- This novel formulation may provide a more efficient and better-tolerated therapeutic option.