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Synthesis and NMR characterization of diastereomeric CPSMeG derivatives
D Machytka1, G Sági, M Kajtár-Peredy
1Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary.
Nucleosides, Nucleotides & Nucleic Acids
|July 14, 2000
Abstract:
Synthesis and stereochemical characterization of enantiomerically pure CPSMeG derivatives by NMR methods are reported. The effect of 5'-dimethoxytrityl on the conformational properties is described. It was found that in P-diastereomers the conformational differences about the C3'-O3' bond, as discernible from the delta J values, are enhanced by the presence of this protecting group.