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Efficient marker-based recurrent selection for multiple quantitative trait loci.

F Hospital1, I Goldringer, S Openshaw

  • 1Station de Génétique Végétale, INRA/UPS/INAPG, Gif sur Yvette, France. fred@moulon.inra.fr

Genetical Research
|July 14, 2000
PubMed
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Marker-based selection effectively increases favorable allele frequencies for quantitative trait loci (QTLs). QTL Complementation Selection (QCS) proved more efficient than marker-based truncation selection (MTS) for improving QTL allele frequency and fixation.

Area of Science:

  • Quantitative genetics
  • Plant breeding
  • Genomic selection

Background:

  • Recurrent selection is a breeding strategy to increase the frequency of desirable alleles.
  • Molecular markers can potentially enhance the efficiency of recurrent selection.
  • Previous studies have explored marker-assisted selection, but its efficiency in recurrent selection needs further investigation.

Purpose of the Study:

  • To evaluate the efficiency of marker-based selection for increasing favorable allele frequencies at quantitative trait loci (QTLs).
  • To compare two marker-based selection procedures: marker-based truncation selection (MTS) and QTL Complementation Selection (QCS).

Main Methods:

  • Computer simulations were used to investigate two marker-based selection procedures.
  • Marker-based truncation selection (MTS) involved ranking individuals by marker score and selecting the best for recombination.

Related Experiment Videos

  • QTL Complementation Selection (QCS) involved selecting individuals to complement the QTL composition of already selected individuals.

    • Main Results:

    • Marker-based selection, with a population size of 200, was highly effective in rapidly increasing favorable QTL allele frequencies, assuming accurate QTL locations.
    • QTL Complementation Selection (QCS) demonstrated superior effectiveness compared to MTS in enhancing the mean frequency and fixation of favorable QTL alleles.
    • Marker-based selection showed resilience to population size reduction, indicating its robustness.

    Conclusions:

    • Marker-based selection is a valuable tool for optimizing the use of molecular markers in recurrent selection programs.
    • QCS offers a more effective approach than MTS for improving QTL allele frequencies and achieving fixation.
    • Accurate QTL location information is crucial for the success of marker-based recurrent selection.