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Permanent deafness associated with furosemide administration.

C A Quick, W Hoppe

    The Annals of Otology, Rhinology, and Laryngology
    |January 1, 1975
    PubMed
    Summary
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    Furosemide may cause permanent hearing loss in transplant patients. This study links the drug to sensorineural hearing impairment, suggesting precautionary measures for ototoxic drug use.

    Area of Science:

    • Nephrology
    • Ototoxicology
    • Transplant Medicine

    Background:

    • Furosemide is a common diuretic used in transplant patients.
    • Hearing impairment is a potential complication in transplant recipients.
    • The specific cause of hearing loss in these cases was unclear.

    Purpose of the Study:

    • To investigate the potential ototoxicity of furosemide in transplant patients.
    • To identify the cause of sensorineural hearing loss in six transplant recipients.
    • To describe the audiometric characteristics of furosemide-induced hearing impairment.

    Main Methods:

    • Case series presentation of six transplant patients with hearing impairment.
    • Clinical assessment and audiometric evaluation of affected patients.

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  • Review of potential confounding factors for hearing loss.

    • Main Results:

    • All patients received furosemide around the onset of deafness.
    • No other known causes of hearing loss were identified in these patients.
    • A distinct audiometric pattern of hearing impairment was observed.

    Conclusions:

    • Furosemide is implicated as the causative agent for permanent sensorineural hearing loss.
    • Experimental evidence supports furosemide's role in stria damage.
    • Recommendations for cautious use of ototoxic drugs are provided.