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Related Experiment Videos

Heart rate variability in dilated cardiomyopathy.

P K Biswas1, S Basu, K K Mitra

  • 1Department of Cardiology, SSKM Hospital, Calcutta.

Indian Heart Journal
|July 14, 2000
PubMed
Summary

Heart rate variability (HRV) is significantly reduced in patients with dilated cardiomyopathy, indicating autonomic imbalance. This study highlights HRV as a valuable tool for assessing heart failure severity and prognosis.

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Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Medical Diagnostics

Background:

  • Chronic heart failure (CHF) is characterized by excessive neurohormonal activation.
  • Heart rate variability (HRV) analysis is a validated method for assessing cardiac autonomic balance.
  • Dilated cardiomyopathy (DCM) is a common form of CHF often associated with autonomic dysfunction.

Purpose of the Study:

  • To investigate heart rate variability parameters in symptomatic patients with dilated cardiomyopathy.
  • To compare HRV in DCM patients with healthy controls.
  • To explore the correlation between HRV and clinical parameters like ejection fraction and NYHA class.

Main Methods:

  • 24-hour Holter monitoring was performed on 20 DCM patients (NYHA class II-IV) and 20 controls.

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  • Time-domain (SDNN, 5-min SD, RMSSD) and frequency-domain (LF, HF, Total Power) HRV analyses were conducted.
  • Ejection fraction and NYHA class were recorded for correlation analysis.

    • Main Results:

    • DCM patients exhibited significantly higher mean heart rate and lower mean hourly heart rate standard deviation compared to controls.
    • Key HRV parameters, including SDNN, 5-min SD, and low-frequency power, were significantly reduced in DCM patients.
    • Reduced HRV parameters correlated significantly with decreased ejection fraction and increased NYHA class.

    Conclusions:

    • Symptomatic dilated cardiomyopathy patients demonstrate significantly impaired heart rate variability compared to healthy individuals.
    • HRV parameters are valuable indicators of autonomic imbalance in DCM.
    • HRV analysis can aid in assessing disease severity and potentially predicting outcomes in DCM patients.