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Related Experiment Videos

[Potential dangers of diuretics...].

U Huynh-Do1, F J Frey

  • 1Abteilung für Nephrologie und Hypertonie, Inselspital Bern. uyen.huynh-do@insel.ch

Therapeutische Umschau. Revue Therapeutique
|July 14, 2000
PubMed
Summary

Chronic diuretic abuse can lead to dangerous fluid retention and edema upon cessation. Gradual tapering of diuretics is crucial, especially in vulnerable populations like pregnant women and those with systemic sclerosis.

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OS067. VEGF, a novel stimulator of aldosterone production.

Pregnancy hypertension·2015

Area of Science:

  • Nephrology
  • Endocrinology
  • Obstetrics

Background:

  • Chronic diuretic abuse is prevalent in young women.
  • Diuretics can cause secondary hyperaldosteronism, leading to sodium retention and edema upon withdrawal.

Observation:

  • Diuretic use in pregnancy can cause plasma volume depletion, potentially leading to placental hypoperfusion and preeclampsia.
  • Patients with systemic sclerosis exhibit high renin levels, making them susceptible to diuretic-induced volume depletion.

Findings:

  • Acute cessation of diuretics in abusers causes edema due to hyperaldosteronism.
  • Diuretic-induced volume depletion in systemic sclerosis patients can precipitate rapidly progressive renal failure (sclerodermal renal crisis).

Implications:

  • Diuretics require careful tapering over weeks or months in chronic abusers.
  • Diuretic therapy is potentially deleterious in pregnancy and systemic sclerosis.
  • Angiotensin Converting Enzyme (ACE) inhibitors may prevent sclerodermal renal crisis.

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