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[Lethal uropathies: prenatal diagnosis and feto-pathologic aspects].

B R Boutheina, M Aïda, S Lamia

    La Tunisie Medicale
    |July 14, 2000
    PubMed
    Summary

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    Prenatal diagnosis identified lethal urinary tract abnormalities in 43 pregnancies. Bilateral renal agenesis was the most common, leading to pregnancy interruption in most cases.

    Area of Science:

    • Medical Genetics
    • Urology
    • Prenatal Diagnosis

    Background:

    • Lethal urinary tract abnormalities pose significant challenges in prenatal diagnosis.
    • Accurate identification is crucial for genetic counseling and management.

    Purpose of the Study:

    • To analyze the spectrum and frequency of lethal urinary tract abnormalities diagnosed prenatally.
    • To report on pregnancy outcomes following diagnosis.

    Main Methods:

    • Retrospective review of prenatal diagnoses over a five-year period.
    • Categorization of identified lethal urinary tract abnormalities.

    Main Results:

    • Forty-three cases of lethal urinary tract abnormalities were diagnosed.
    • Bilateral renal agenesis (56%) was the most frequent diagnosis.

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  • Autosomal recessive polycystic kidney disease (16%) and autosomal dominant polycystic kidney disease (14%) were also significant.
  • Pregnancy was interrupted in 81.4% of cases.

    • Conclusions:

    • Prenatal diagnosis of lethal urinary tract abnormalities is critical.
    • Bilateral renal agenesis is the predominant condition.
    • High rates of pregnancy interruption underscore the severity of these conditions.