Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Isolated intestinal transplantation for intestinal failure.

D L Sudan1, S S Kaufman, B W Shaw

  • 1Department of Surgery, University of Nebraska Medical Center, Omaha 68198-3285, USA.

The American Journal of Gastroenterology
|July 14, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limitations of antifungal prophylaxis in preventing invasive <i>Candida</i> surgical site infections after liver transplant surgery.

Antimicrobial agents and chemotherapy·2024
Same author

Development of a Telehealth Intervention to Improve Access to Live Donor Kidney Transplantation.

Transplantation proceedings·2019
Same author

The Incremental Cost of Incompatible Living Donor Kidney Transplantation: A National Cohort Analysis.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Surgical technique in transplantation: how much does it matter?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

AST/ASTS workshop on increasing organ donation in the United States: creating an "arc of change" from removing disincentives to testing incentives.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Parvovirus associated fulminant hepatic failure and aplastic anemia treated successfully with liver and bone marrow transplantation. A report of two cases.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014

Intestinal transplantation offers a lifesaving option for patients with intestinal failure, showing comparable survival rates to parenteral nutrition. However, improved immunosuppression is crucial to reduce graft loss from rejection.

Area of Science:

  • Gastroenterology
  • Transplant Surgery
  • Immunology

Background:

  • Parenteral nutrition is essential for patients with intestinal failure.
  • Life-threatening complications can arise from parenteral nutrition.
  • Intestinal transplantation serves as a potentially lifesaving intervention for select patients.

Purpose of the Study:

  • To evaluate patient and graft survival rates after isolated small bowel transplantation.
  • To identify causes of graft loss and complications.
  • To assess the reversibility of pre-existing liver dysfunction.

Main Methods:

  • Retrospective review of 28 consecutive isolated small bowel transplants.
  • Data collected from adult and pediatric patients between December 1993 and June 1998.

Related Experiment Videos

  • Analysis of patient and graft survival, causes of graft loss, and complication rates.

    • Main Results:

    • One-year patient survival was 93%, and graft survival was 71%.
    • Acute rejection was the primary cause of graft loss (5/28), occurring in all patients.
    • Preoperative jaundice and hepatic fibrosis were reversed in patients with functional grafts; 11% developed post-transplant lymphoproliferative disease.

    Conclusions:

    • Intestinal transplantation survival is comparable to parenteral nutrition for intestinal failure.
    • Enhanced immunosuppressive strategies are needed to minimize acute rejection and graft loss.
    • Post-transplant lymphoproliferative disorder incidence is higher than in other solid organ transplants; cytomegalovirus enteritis risk is low with seronegative donors.