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Genomic structure and chromosome location of the mouse RelA p65 gene (Rela)
E R Lemmer1, J L Welch, T Tsai
1Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cytogenetics and Cell Genetics
|July 15, 2000
Abstract:
The RelA (p65) subunit of transcription factor NF-kappaB plays a critical role in development, and rela(-/-) knockout mice die in utero from massive liver apoptosis. Only partial sequences of the mouse Rela gene are available. We have determined the genomic structure of mouse Rela and promoter, and have mapped the gene to chromosome 19B1-3.