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HLA-DRB genotypes in Japanese patients with renal cell carcinoma
Y Kojima1, S Takahara, N Nonomura
1Department of Urology, Osaka University Medical School, Osaka, Japan.
Objectives:
Several clinical features, such as the spontaneous regression of some renal cell carcinoma (RCC) metastases after nephrectomy, suggest immune involvement in tumor destruction.
Patients And Methods:
We investigated the role of genetic variation at the HLA class II loci in RCC by analyzing the HLA-DR antigen and HLA-DRB1, DRB3, DRB4 and DRB5 alleles in 55 patients using the polymerase chain rection.
Results:
No statistically significant differences were observed in the frequency of the HLA-DR antigen or HLA-DRB3, DRB4, or DRB5 genes between the patients and a healthy control group. On the other hand, the HLA-DRB1*0403 and *1202 alleles were significantly more frequent in the patients than in the controls (p < 0.001 and p < 0.01, respectively).
Conclusion:
RCC might be linked to these two alleles in Japanese patients.