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Related Experiment Videos

Microdochectomy for single-duct nipple discharge.

L Wong1, Y F Chung, C Y Wong

  • 1Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore.

Annals of the Academy of Medicine, Singapore
|July 15, 2000
PubMed
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Isolated single-duct nipple discharge in women has a low incidence of breast cancer (5%). Blood-stained discharge was common in malignancy cases, but no reliable predictors were found. Microdochectomy is an effective diagnostic and treatment method.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Breast Surgery

Background:

  • Isolated single-duct nipple discharge presents a diagnostic challenge.
  • Predictive factors for malignancy in such cases remain controversial.
  • This condition often necessitates surgical intervention, creating a dilemma for clinicians.

Purpose of the Study:

  • To evaluate the incidence of breast carcinoma in patients with isolated single-duct nipple discharge.
  • To identify any reliable predictors of malignancy in this patient group.
  • To assess the efficacy of microdochectomy for diagnosis and treatment.

Main Methods:

  • Retrospective review of 92 microdochectomies for single-duct nipple discharge.
  • Study conducted over 8 years at a tertiary referral center.

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  • Analysis of patient demographics, discharge characteristics, and histopathological findings.

    • Main Results:

    • Ductal papilloma (52%) and fibrocystic disease (21%) were the most common benign causes.
    • Breast carcinoma was diagnosed in 5% of patients, with only one invasive component.
    • Blood-stained discharge was present in all carcinoma patients; mammography was abnormal in only 1 of 4.

    Conclusions:

    • The incidence of breast carcinoma associated with isolated single-duct nipple discharge is low (5%) in Singaporean women.
    • No definitive predictors of malignancy were identified, although blood-stained discharge was a consistent feature in cancer cases.
    • Microdochectomy is confirmed as an effective surgical approach for both diagnosing and treating nipple discharge.