New antiepileptic drugs in children: which ones for which seizures?

Until 1993, carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA) accounted for the great majority of the prescriptions written for the treatment of epilepsy. Since 1993, five antiepileptic drugs (AEDs) have been released in the United States, and at least three additional drugs are expected to be released by the end of the year 2000. As a group, these newer drugs differ from the established drugs in terms of their pharmacokinetics, interaction potential, and adverse effects. In addition, any one of the newer drugs may achieve seizure control in situations in which an established drug had not. The newer drugs certainly represent a welcome addition to the existing options for the treatment of epilepsy in children. However, the availability of several new AEDs represents a therapeutic dilemma for the clinician because optimal use of these drugs has not yet been established. This is particularly true in children because (i) newer drugs are often studied less frequently in children, (ii) pharmacokinetics in children differ from those in adults, (iii) children may have different adverse effects, and (iv) children have a broader spectrum of various seizure types and epilepsy syndromes. In the first part of this review, the clinical pharmacology of the currently available newer AEDs is discussed individually, with special emphasis on data in children. In particular, pharmacokinetics, interactions, dosage and titration, efficacy spectrum, and adverse effect profile is discussed for each drug. In the second part, an attempt is made to determine the place for the newer drugs in the treatment of the different pediatric seizures and epilepsy syndromes.