Related Experiment Videos
Risk factors for coronary artery disease in old persons in an academic hospital-based geriatrics practice
1Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA.
Insights
This study found that in older adults, cigarette smoking in men, hypertension in both sexes, and LDL cholesterol levels are significant risk factors for coronary artery disease (CAD). HDL cholesterol showed an inverse association, suggesting a protective effect against CAD.
Area of Science:
- Geriatric Medicine
- Cardiovascular Disease Epidemiology
- Public Health
Background:
- Coronary Artery Disease (CAD) is a significant health concern in the elderly population.
- Established risk factors for CAD include age, smoking, hypertension, diabetes, dyslipidemia, and obesity.
Purpose of the Study:
- To examine the association between various risk factors and the prevalence of Coronary Artery Disease (CAD) in an elderly cohort.
- To identify independent predictors of CAD in older men and women.
Main Methods:
- Retrospective analysis of medical records from an academic hospital-based geriatric practice.
- Inclusion of 467 men (mean age 80) and 1444 women (mean age 81).
- Statistical analysis including univariate and stepwise logistic regression.
Main Results:
- CAD prevalence was higher in men (43%) than women (33%).
- Univariate analysis identified age, smoking, hypertension, diabetes, obesity, total cholesterol, LDL, and HDL cholesterol as risk factors.
- Independent predictors of CAD included smoking (men), hypertension (men & women), LDL cholesterol (men & women), and HDL cholesterol (inverse association, men & women).
Conclusions:
- Cigarette smoking in men, hypertension in both sexes, and serum LDL cholesterol levels are significant independent risk factors for CAD in the elderly.
- Serum HDL cholesterol demonstrated an inverse association, indicating a protective effect against CAD in older individuals.
Background:
Risk factors for coronary artery disease (CAD) in old men and women include age, cigarette smoking, hypertension, diabetes mellitus, dyslipidemia, and obesity.
Objective:
To investigate the association of risk factors with prevalence of CAD.
Methods:
We performed a retrospective analysis of charts for all old persons seen during the period from 1 January 1998 through 15 June 1999 at an academic hospital-based geriatric practice to investigate associations of risk factors with prevalence of CAD among old persons. We studied 467 men, mean age 80 +/- 8 years, and 1444 women, mean age 81 +/- 8 years.
Results:
CAD was present in 201 of 467 men (43%) and in 473 of 1444 women (33%; P < 0.0001). Risk factors for CAD according to univariate analysis were age (P < 0.0001 for women), cigarette smoking (P < 0.0001 for men and women), hypertension (P < 0.0001 for men and women), diabetes mellitus (P < 0.0001 for men and women), obesity (P < 0.0001 for men and women), and serum levels of total cholesterol (P < 0.0001 for men and P = 0.0001 for women), low-density lipoprotein (LDL) cholesterol (P < 0.0001 for men and P = 0.001 for women), and high-density lipoprotein (HDL) cholesterol (inverse association; P = 0.0001 for men and women). Stepwise logistic regression analysis showed that significant independent risk factors for CAD were cigarette smoking (odds ratio 6.7 for men), hypertension (odds ratios 3.3 for men and 2.7 for women), and serum levels of HDL cholesterol (odds ratio 0.83 for men and women) and LDL cholesterol (odds ratios 1.10 for men and 1.09 for women).
Conclusions:
Significant independent risk associations with prevalence of CAD among old persons were found for cigarette smoking by men, hypertension in men and women, and serum levels of HDL cholesterol (inverse association) in men and women, and of LDL cholesterol in men and women.