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Aromatase inhibitors from Isodon excisus var. coreanus
H J Jeong1, L C Chang, H K Kim
1PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, USA. Hyehjean@nmdhst.cc.nih.gov
Archives of Pharmacal Research
|July 15, 2000
Abstract:
The diethyl ether extract of Isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin (ent-1alpha-hydroxy-3beta,6a-diacetoxykaur-16-en-11,15-dione ) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).