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Plasma TAFI antigen variations in healthy subjects
P Chetaille1, M C Alessi, D Kouassi
1Laboratory of Hematology, University of Medicine La Timone, Marseille, France.
Thrombosis and Haemostasis
|July 15, 2000
Summary
Plasma levels of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) vary widely between individuals but remain stable within them. Factors like age and ethnicity influence TAFI antigen levels in healthy adults.
Area of Science:
- Biochemistry
- Hematology
- Physiology
Background:
- Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a key regulator of fibrinolysis.
- Understanding physiological variations in plasma TAFI antigen levels is crucial but not well-established.
Purpose of the Study:
- To investigate the physiological variations of plasma TAFI antigen in healthy individuals.
- To identify factors influencing TAFI antigen levels, such as age, gender, pregnancy, and ethnicity.
Main Methods:
- Utilized a commercially available kit from Milan Analytica for TAFI antigen measurement.
- Analyzed plasma samples from 249 healthy individuals.
- Statistical analysis to assess correlations with age, gender, pregnancy, and ethnic groups.
Main Results:
- Observed a broad range of TAFI antigen values (41%-259%) in the healthy population.
- Neither gender nor pregnancy significantly affected mean TAFI antigen levels.
- A positive correlation between TAFI antigen and age was found in females (r=0.28, p<0.05).
- Black African males exhibited significantly lower mean TAFI antigen levels compared to age-matched Caucasian males (p<0.0001).
- TAFI antigen levels demonstrated high intra-individual stability over time (daytime and several months).
Conclusions:
- Plasma TAFI antigen levels exhibit substantial inter-individual variability but are remarkably stable within individuals.
- Age and ethnicity are significant factors influencing TAFI antigen levels in healthy adults.
- These findings provide essential reference ranges for TAFI antigen in diverse populations.