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Synovial sarcoma in an Ayrshire heifer
C Tremblay1, C Girard, P Dubreuil
1Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec, Canada. tremc@magellan.umontreal.ca
Veterinary Pathology
|July 15, 2000
Summary
A rare poorly differentiated synovial sarcoma was diagnosed in an 8-month-old heifer. This veterinary cancer case highlights diagnostic challenges and features similar to human synovial sarcomas.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Skeletal Tumors in Animals
Background:
- Synovial sarcomas are rare soft tissue tumors, typically affecting young adults.
- In animals, synovial sarcomas are infrequently reported, often presenting diagnostic challenges.
- This case involves an 8-month-old Ayrshire heifer with a rapidly growing axillary mass.
Observation:
- The mass encasing the distal humerus and brachial plexus nerves caused an abnormal gait.
- Histological examination revealed nests and cords of round to polygonal cells with scattered spindle cells.
- Immunohistochemistry showed positivity for vimentin and cytokeratin, with negative results for S-100 protein and lymphoid markers.
Findings:
- Ultrastructural analysis demonstrated neoplastic cells with abundant rough and smooth endoplasmic reticulum and mitochondria.
- The tumor exhibited histological and ultrastructural characteristics consistent with the poorly differentiated subtype of synovial sarcoma.
- Immunophenotype and morphology align with human classification of poorly differentiated synovial sarcoma.
Implications:
- This case expands the understanding of synovial sarcoma occurrence and presentation in young cattle.
- The findings support the utility of immunohistochemistry and electron microscopy in diagnosing challenging veterinary neoplasms.
- Comparing this bovine synovial sarcoma to human counterparts offers insights into comparative oncology and potential therapeutic strategies.