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Related Experiment Videos

Valproic acid-induced hyperammonemic encephalopathy with triphasic waves.

A Kifune1, F Kubota, N Shibata

  • 1Department of Neuropsychiatry, Gunma University School of Medicine, Gunma, Japan.

Epilepsia
|July 18, 2000
PubMed
Summary
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Valproic acid (VPA) can cause hyperammonemic encephalopathy, a serious condition. Triphasic waves on EEG in patients taking VPA may indicate this adverse effect, requiring prompt discontinuation of the drug.

Area of Science:

  • Neurology
  • Clinical Toxicology

Background:

  • Valproic acid (VPA) is a widely used antiepileptic drug.
  • Hyperammonemic encephalopathy is a potential adverse effect of VPA, particularly with dose increases.
  • Triphasic waves on electroencephalogram (EEG) are an abnormal finding that can be associated with metabolic encephalopathies.