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An antimalarial stilbene from Artocarpus integer
C Boonlaksiri1, W Oonanant, P Kongsaeree
1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Phytochemistry
|July 18, 2000
Abstract:
Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data.