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[Total antioxidant status (TAS) in children with nephrotic syndrome]
J Zachwieja1, W Bobkowski, A Niklas
1Kliniki Chorób Dzieci Instytutu Pediatrii Akademii Medycznej w Poznaniu.
Unlabelled:
The aim of the study was to estimate total antioxidant status (TAS) as the most reliable factor involved in antioxidant protection in children with nephrotic syndrome. 28 children with NS (12 with first episode and 16 with relapse NS) aged 4-16 were included into the study. TAS was estimated using two-regent Randox Total Antioxidant Status test in plasma. Laboratory investigations were performed before steroid treatment.
Results:
1) in children with NS TAS was significantly reduced comparing to controls (0.81 +/- 0.14; 1.21 +/- 0.62 mmol/L; p = 0.002), 2) negative correlation between Tchol and LDL and TAS was found (TAS vs Tchol p = 0.0005, R = 0.61; TAS vs LDL p = 0.03, R = 0.41), 3) TAS was higher in children with the first episode of NS comparing to children with following relapse (0.88 +/- 0.07; 0.75 +/- 0.16; mmol/l; p = 0.14).
Conclusion:
In children with NS reduced antioxidant protection is one of the factors leading to renal injury and may be a consequence a cause reason of lipids abnormalities.