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Immune complexes in cancer: demonstration of complexes in mice bearing neuroblastomas

M B Oldstone

    Journal of the National Cancer Institute
    |January 1, 1975
    PubMed

    Immune complexes occurred in a large proportion of mice with syngeneic neuroblastomas. Circulating immune complexes formed in all mice, whereas almost 50% had deposits of host IgG and complement in a granular pattern along the mesangia and basement membranes of the renal glomeruli. The bound IgG was eluted and recovered from the glomeruli and demonstrated immunologic specificity to neuroblastoma cell-surface antigens.

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