Related Experiment Videos
Increased expression of CD23 in rheumatoid synovitis
A P Huissoon1, P Emery, P A Bacon
1Rheumatology and Rehabilitation Research Unit, University of Leeds, UK.
Scandinavian Journal of Rheumatology
|July 18, 2000
Summary
Soluble CD23 (sCD23) is elevated in rheumatoid arthritis (RA) synovial fluid, primarily from macrophages. These cells also express sCD23 ligands, suggesting a role in RA inflammation.
Area of Science:
- Immunology
- Rheumatology
Background:
- Soluble CD23 (sCD23) is a known macrophage stimulator.
- Elevated sCD23 levels are observed in rheumatoid arthritis (RA) serum.
Purpose of the Study:
- To investigate the expression of CD23 and its ligands in RA synovial fluid and cells.
- To determine the source and target cells of sCD23 in RA.
Main Methods:
- Quantified sCD23 levels in synovial fluid (SF) and serum from RA patients and controls.
- Assessed cellular expression of CD23, CD21, CD11b, and CD11c in RA SF and blood.
Main Results:
- SF showed significantly higher sCD23 levels compared to RA and normal sera.
- CD23 was mainly expressed on macrophages in RA synovial tissue.
- Macrophages highly expressed CD11b and CD11c, ligands for sCD23.
Conclusions:
- High sCD23 concentrations are found in RA synovial fluid.
- Macrophages are identified as the primary source and potential target of sCD23 in RA.
- sCD23 may contribute to RA pathogenesis through macrophage activation and signaling.