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Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
G Carlucci1, G Palumbo, P Mazzeo
1Dipartimeto di Chimica, Ingegneria Chimica e Materiali, Università dell'Aquila, Coppito (L'Aquila), Italy. carlucci@aquila.infn.it
Journal of Pharmaceutical and Biomedical Analysis
|July 18, 2000
Abstract:
A method for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration range 3.0-7.0 microg ml(-1) for losartan and 0.5-2.0 microg ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 0.08 microg ml(-1) for losartan and 0.05 microg ml(-1) for hydrochlorothiazide.