Common egg envelope antigens are limited to the animal class
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Updated: Oct 15, 2026

Probing the Limits of Egg Recognition Using Egg Rejection Experiments Along Phenotypic Gradients
Published on: August 22, 2018
S Kalaydjiev1, M Vasilevska, L Nakov
1Department of Biology, Medical University, Sofia, Bulgaria.
Abstract:
The antigens of the egg envelope (zona pellucida) in mammals are of special interest because of their possible involvement in immunoinfertility and as candidate targets for immunocontraception. Conserved zona epitopes from divergent species may present a suitable source and an animal model for investigation of the above factors. We compared egg envelope antigens from 6 species of vertebrates belonging to 3 different classes in order to demonstrate the existence of shared antigens. Egg envelopes from the trout, carp, turtle, hen, duck and quail were isolated and heat-solubilized. They were tested with rabbit polyclonal antisera against carp, trout and duck egg envelopes by the enzyme-linked immunosorbent assay. The results showed significant cross-reactions among egg envelopes of fish and birds. The examined solubilized preparations did not show cross-reactivity with egg envelopes from any other class, suggesting that divergent species did not share common egg envelope antigens, and that their use may not be appropriate in the investigation of immunoinfertility and immunocontraception in humans.
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