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Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled
R A Skyrme-Jones1, R C O'Brien, K L Berry
1Centre for Heart and Chest Research, Monash Medical Centre and Monash University, Melbourne, Australia.
Journal of the American College of Cardiology
|July 18, 2000
Summary
Vitamin E supplementation improved endothelial vasodilator function in young adults with type 1 diabetes. This vitamin E therapy enhanced blood vessel function, showing potential benefits for managing diabetes complications.
Area of Science:
- Endocrinology
- Cardiovascular Research
- Nutritional Science
Background:
- Oxidative stress is implicated in endothelial vasodilator dysfunction (EVF) in type 1 diabetes.
- Low-density lipoprotein (LDL) vitamin E content (VEC) correlates with impaired EVF in young type 1 diabetes patients.
Purpose of the Study:
- To investigate if vitamin E supplementation improves EVF and systemic arterial compliance (SAC) in type 1 diabetes.
- To assess the impact of 1,000 IU vitamin E daily for three months in a randomized, placebo-controlled trial.
Main Methods:
- Assessed EVF via brachial artery flow-mediated dilation (FMD) and forearm resistance vessel response to acetylcholine.
- Measured SAC using simultaneous aortic blood flow and carotid pressure.
- Analyzed changes in LDL vitamin E content and oxidative susceptibility.
Main Results:
- Vitamin E increased LDL VEC by 127%, reducing LDL oxidative susceptibility.
- Significant improvements in FMD and acetylcholine response were observed with vitamin E.
- Systemic arterial compliance (SAC) remained unaffected by vitamin E supplementation.
Conclusions:
- Short-term oral vitamin E supplementation effectively enhances endothelial vasodilator function in conduit and resistance vessels.
- Vitamin E shows promise for improving vascular health in young individuals with type 1 diabetes.