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In vitro activity and fecal concentration of rifaximin after oral administration

Z D Jiang1, S Ke, E Palazzini

  • 1Center for Infectious Disease, School of Public Health and Medical School, University of Texas-Houston, Houston, Texas 77030, USA. ZJIANG@UTSPH.SPH.UTH.TMC.EDU

Antimicrobial Agents and Chemotherapy
|July 18, 2000
PubMed

Insights

Rifaximin demonstrated moderately high MICs against bacterial enteropathogens causing traveler's diarrhea. However, high concentrations were found in stool after oral administration, confirming its effectiveness for treating the condition.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Traveler's diarrhea is a common gastrointestinal illness, often caused by bacterial enteropathogens.
  • Rifaximin is a non-absorbed antibiotic used to treat bacterial infections.

Purpose of the Study:

  • To evaluate the in vitro activity of rifaximin against bacterial enteropathogens causing traveler's diarrhea.
  • To determine rifaximin concentrations in stool following oral administration.

Main Methods:

  • Minimum Inhibitory Concentrations (MICs) were determined for 145 bacterial enteropathogen isolates.
  • Rifaximin concentrations in stool were measured after a 3-day oral administration regimen (800 mg daily).

Main Results:

  • Rifaximin exhibited moderately high MICs (50 microg/ml) against the tested enteropathogens.
  • Average rifaximin concentrations in stool reached 7,961 microg/g one day after administration.

Conclusions:

  • Rifaximin shows potential for treating traveler's diarrhea despite moderately high MICs.
  • High drug concentrations achieved in the gut confirm rifaximin's therapeutic value for this condition.

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