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Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori
1Department of Endoscopy, Hokkaido University School of Medicine, Sapporo, Japan.
Antimicrobial Agents and Chemotherapy
|July 18, 2000
Abstract:
The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).