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BCoR, a novel corepressor involved in BCL-6 repression
K D Huynh1, W Fischle, E Verdin
1Biochemistry, Molecular Biology, and Biophysics Program, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Genes & Development
|July 18, 2000
Summary
Researchers identified BCL-6 interacting corepressor (BCoR), a novel protein that interacts specifically with BCL-6. This discovery may illuminate the role of BCoR in BCL-6-associated lymphomas.
Area of Science:
- Molecular Biology
- Cancer Biology
- Gene Regulation
Background:
- BCL-6 is a transcriptional repressor crucial for germinal center formation, with aberrant expression linked to non-Hodgkin's lymphoma.
- The POZ domains of BCL-6 and other POZ proteins interact with corepressors like N-CoR and SMRT.
Purpose of the Study:
- To identify and characterize a novel corepressor interacting with BCL-6.
- To investigate the functional significance and interaction specificity of this new corepressor.
Main Methods:
- Identification and characterization of the BCL-6 interacting corepressor (BCoR).
- In vivo interaction studies between BCoR, BCL-6, and other POZ proteins.
- Analysis of histone deacetylase (HDAC) interactions with BCoR.
Main Results:
- BCoR, a novel ubiquitously expressed corepressor, potentiates BCL-6 repression when overexpressed.
- BCoR interacts selectively with the BCL-6 POZ domain, and these interactions are mutually exclusive with SMRT and N-CoR binding.
- BCoR interacts with class I and II histone deacetylases (HDACs).
Conclusions:
- BCoR is a specific interacting partner of BCL-6.
- The selective interaction suggests a potential role for BCoR in BCL-6-associated lymphomas.
- BCoR may functionally link BCL-6 repression with HDAC activity.