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DNA topology: feeling the pulse of a topoisomerase
1Laboratoire d'Analyse Ultrastructurale, Bätiment de Biologie, Universté de Lausanne, Lausanne-Dorigny, CH-1015, Switzerland. Andrzej.Stasiak@lau.unil.ch.
Current Biology : CB
|July 19, 2000
Abstract:
The action of individual type II DNA topoisomerases has been followed in real time by observing the elastic response of single DNA molecules to sequential strand passage events. Micromanipulation methods provide a complementary approach to biochemical studies for investigating the mechanism of DNA topoisomerases.