Related Experiment Videos
Functions of tetramer-stained HIV-specific CD4(+) and CD8(+) T cells
A D Kelleher1, S L Rowland-Jones
1Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK. kelleher@worf.molbiol.ox.ac.uk
Current Opinion in Immunology
|July 19, 2000
Abstract:
Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HIV infection remains to be determined.