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The CD4(+) T cell response to HIV-1.

L J Picker¹, V C Maino

¹Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Mail Code L220, Portland, OR 97201-3098, USA. pickerl@ohsu.edu

Current Opinion in Immunology

|July 19, 2000

Summary

The role of HIV-1-specific CD4(+) T cells in controlling chronic viral infections remains debated. New methods for analyzing these T cells may clarify their function in anti-HIV-1 host defense.

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Area of Science:

Immunology
Virology
Infectious Diseases

Background:

Virus-specific CD4(+) T cells are crucial for controlling chronic viral infections in many models.
The existence and role of HIV-1-specific CD4(+) T cells in human HIV-1 infection are controversial.

Purpose of the Study:

To investigate the role and function of HIV-1-specific CD4(+) T cells in human HIV-1 infection.
To clarify the participation of these cells in anti-HIV-1 host defense.

Main Methods:

Utilizing recent advances in quantifying HIV-1-specific T cells.
Employing functional characterization techniques for HIV-1-specific T cells.

Main Results:

Advances in T cell quantification and functional characterization are providing new insights.
Potential evidence for the role of HIV-1-specific CD4(+) T cells in host defense is emerging.

Conclusions:

Recent technological advancements are crucial for understanding T cell responses in HIV-1 infection.
Further research using these methods may resolve the controversy surrounding HIV-1-specific CD4(+) T cells.

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