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Related Experiment Videos

Dopamine D(1) agonist activates temporal lobe structures in primates.

K J Black1, T Hershey, M H Gado

  • 1Department of Psychiatry, Missouri 63110, USA. kevin@npg.wustl.edu

Journal of Neurophysiology
|July 19, 2000
PubMed
Summary
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Dopamine D(1) agonists significantly increase blood flow in the temporal lobe, including the amygdala, in baboons. These findings in brain imaging may explain how dopamine D(1) receptors influence mood disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Dopamine D(1) pathways are implicated in various human diseases.
  • Functional imaging methods were developed for nonhuman primate studies.
  • Dopamine agonists' effects on brain activity require in vivo mapping.

Purpose of the Study:

  • To map brain responses to dopamine D(1) agonists using functional imaging.
  • To investigate the in vivo effects of SKF82958, a D(1) agonist, on regional cerebral blood flow (rCBF).
  • To explore the role of D(1) receptors in temporal lobe and amygdala activity.

Main Methods:

  • Positron emission tomography (PET) was used in seven baboons.
  • Regional cerebral blood flow (rCBF) was measured following an acute dose of SKF82958.

Related Experiment Videos

  • Dose-dependent responses and drug half-life were analyzed.

    • Main Results:

    • Significant rCBF increases (6-17%) were observed in the bilateral temporal lobe, including the amygdala and superior temporal sulcus (P < 0.001).
    • rCBF decreased in the thalamus, pallidum, and pons (4-7%, P = 0.001).
    • Responses were dose-dependent with a half-life of approximately 30 min, suggesting neuronal effects.

    Conclusions:

    • Dopamine D(1) agonism prominently activates the temporal lobe, particularly the amygdala.
    • This activation pattern supports the hypothesis that D(1) receptors mediate some of levodopa's mood effects in humans.
    • The study provides in vivo evidence for D(1) receptor-mediated neuronal activity in primates.