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Related Experiment Videos

Increased D-dimer levels in twin gestation.

J Bar1, D Blickstein, M Hod

  • 1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel. jbar@clalit.org.il

Thrombosis Research
|July 19, 2000
PubMed
Summary
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Pregnancy alters blood clotting, increasing risks. Multifetal gestation further exaggerates these hemostatic changes, though typically without clear clinical signs of coagulopathy.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Physiological Adaptations to Pregnancy

Background:

  • Normal pregnancy shifts hemostasis towards hypercoagulability, increasing thromboembolism risk.
  • Elevated coagulation factors and plasminogen activator inhibitors contribute to this shift.
  • Multifetal gestation necessitates greater physiological adaptations, further exaggerating hemostatic imbalances.

Purpose of the Study:

  • To investigate the hemostatic changes associated with multiple gestation.
  • To understand the biological adaptations in coagulation during multifetal pregnancy.
  • To clarify the extent of hemostatic alterations in multiple gestations compared to normal pregnancies.

Main Methods:

  • Review of existing literature on hemostasis in pregnancy.

Related Experiment Videos

  • Analysis of physiological changes in coagulation factors and inhibitors.
  • Comparison of hemostatic profiles in singleton versus multifetal gestations.

    • Main Results:

    • Multifetal gestation significantly exaggerates the hypercoagulable state seen in normal pregnancy.
    • Laboratory findings may mimic low-grade disseminated intravascular coagulopathy near term.
    • Despite laboratory changes, clinical coagulopathy is generally not apparent in most multifetal gestations.

    Conclusions:

    • The hemostatic system undergoes profound, exaggerated adaptations in multifetal gestation.
    • While laboratory markers suggest increased coagulopathy, clinical manifestations are rare.
    • Further research is needed to fully elucidate these hemostatic adaptations in multiple gestations.