Related Experiment Videos
Formulation and evaluation of Methocel K15M bioadhesive matrix tablets
1University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Drug Development and Industrial Pharmacy
|July 20, 2000
Summary
Methocel K15M exhibits strong bioadhesive properties, with optimal adhesion in the duodenum at pH 5-6. Formulations with chlorpheniramine maleate and diclofenac sodium showed varied release profiles.
Area of Science:
- Polymer science
- Pharmaceutics
- Biomaterials
Background:
- Methocel K15M is a bioadhesive polymer with potential pharmaceutical applications.
- Understanding its adhesion characteristics is crucial for drug delivery systems.
Purpose of the Study:
- To evaluate the adhesion and bioadhesion properties of Methocel K15M.
- To investigate the influence of pH and intestinal location on adhesion.
- To formulate and study the in vitro release of drugs from Methocel K15M matrix tablets.
Main Methods:
- Adhesion and bioadhesion were assessed using shear stress and detachment force measurements.
- The effect of pH on adhesion was examined.
- Adhesion was tested across different segments of the sheep intestine.
- In vitro drug release studies were conducted on matrix tablets containing chlorpheniramine maleate and diclofenac sodium.
Main Results:
- Maximum adhesion of Methocel K15M was observed between pH 5 and pH 6.
- The duodenal portion of the sheep intestine showed the highest adhesion strength.
- Drug release from matrix tablets exhibited a transition from first-order to zero-order kinetics in some formulations.
Conclusions:
- Methocel K15M demonstrates significant bioadhesive potential, particularly in the duodenal region and at specific pH levels.
- The polymer can be effectively formulated into matrix tablets for controlled drug release.
- These findings support the use of Methocel K15M in developing targeted drug delivery systems.