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Updated: Oct 15, 2026

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry
Published on: January 19, 2020
[Semiquantitative evaluation of autoregulation of cerebral blood supply in norm]
Abstract:
Elaboration of an informative, noninvasive method for evaluation of the reserve of the cerebral circulation is an urgent problem of angioneurology. The authors propose a method of dopplerographic estimation of the autogerulatory response by hyperthermic changes after short-term period of regional hypotension induced by digital compression of carotid artery on the neck. The indices acceptable in daily clinical practice were calculated. There was determined a range of their values at normal tonus of the resistive vessels, on the background of hypo- and hypertension induced by hypercapnic and hypocapnic loads, respectively. Test of carotid compression with registration of the linear velocity of blood flow in cerebral arteries is safe, significant and reproducible way for a semiquantitative estimation of the reserve of autoregulation. It may be used for evaluation of tonus of resistant vessels of the reservoir of the middle carotid artery as one of the most important index of the functional state of the system of cerebral circulation.
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