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Isoprostanes quickly normalize after quitting cigarette smoking in healthy adults
A Oguogho1, G Lupattelli, B Palumbo
1Department of Nuclear Medicine, University of Vienna, Austria.
Background:
Isoprostanes and in particular 8-epi-PGF2 alpha have been claimed as a useful measure for invivo oxidation injury. While smokers show elevated 8-epi-PGF2 alpha the behaviour during quitting smoking is unknown.
Methods And Results:
We determined 8-epi-PGF2 alpha in 7 healthy adults ready to quit smoking in plasma, serum and urine by means of an enzyme immunoassay after extraction and purification before quitting smoking and during a follow-up period of 4 weeks. After quitting smoking, 8-epi-PGF2 alpha shows a rapid decline within a few days almost completely normalizing within 4 weeks.
Conclusion:
The cigarette-smoking associated invivo oxidation injury almost completely disappears within 4 weeks of quitting smoking.