Novel therapeutic targets in multiple myeloma

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Updated: Oct 9, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

F E Davies1, K C Anderson

  • 1Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

European Journal of Haematology
|July 20, 2000
PubMed

Insights

Multiple myeloma is incurable, but new therapies targeting tumor cells and the bone marrow microenvironment show promise. Advances in understanding disease biology are paving the way for novel treatments and potentially a cure.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Multiple myeloma is a currently incurable hematologic malignancy.
  • Novel therapeutic strategies are needed to improve patient outcomes.

Purpose of the Study:

  • To review recent advances in multiple myeloma biology.
  • To highlight novel therapeutic approaches based on disease pathogenesis.
  • To discuss strategies for achieving complete tumor eradication and long-term remission.

Main Methods:

  • Review of current scientific literature on multiple myeloma.
  • Analysis of biological factors influencing myeloma cell growth and survival.
  • Examination of the role of the bone marrow microenvironment.

Main Results:

  • Understanding disease pathogenesis has led to the identification of novel therapeutic targets.
  • Biologically based treatments targeting tumor cells and the microenvironment are under development.
  • These approaches aim for more complete eradication and maintenance of minimal residual disease.

Conclusions:

  • Advances in understanding multiple myeloma biology offer new therapeutic avenues.
  • Targeting both the tumor and its microenvironment may improve disease-free survival.
  • Novel treatments hold potential for achieving a cure for multiple myeloma.

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