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Related Experiment Videos

Potential interactions between alternative therapies and warfarin.

A M Heck1, B A DeWitt, A L Lukes

  • 1School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA. amheck@iupui.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|July 21, 2000
PubMed
Summary
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Many alternative therapies, including herbs, may interact with warfarin, increasing bleeding risks. Healthcare providers should screen patients for alternative therapy use to prevent dangerous drug interactions.

Area of Science:

  • Pharmacology
  • Integrative Medicine
  • Drug Safety

Background:

  • An estimated 33% of US adults use alternative therapies, including herbal products.
  • Interactions between alternative therapies and prescription drugs pose significant safety concerns, particularly for medications with narrow therapeutic indexes like warfarin.
  • Warfarin therapy requires careful management due to its narrow therapeutic index and potential for interactions.

Purpose of the Study:

  • To discuss potential and documented interactions between alternative therapy agents and warfarin.
  • To highlight the safety implications of alternative medicine use in patients on warfarin therapy.
  • To inform healthcare professionals about the risks associated with concurrent use of alternative therapies and warfarin.

Main Methods:

Related Experiment Videos

  • Review of potential and documented interactions between alternative therapies and warfarin.
  • Analysis of available data, including in vitro studies, animal research, and case reports.
  • Identification of specific herbal products and supplements associated with warfarin interactions.

Main Results:

  • Numerous herbal products (e.g., garlic, ginger, ginkgo, ginseng) may potentiate warfarin's effects or increase bleeding risk.
  • Documented interactions with warfarin have been reported for supplements such as coenzyme Q10, green tea, and vitamin E.
  • Current evidence is largely based on preliminary data, necessitating further research to confirm clinical significance.

Conclusions:

  • A wide array of alternative therapy products possess the potential to interact with warfarin.
  • Healthcare professionals must proactively inquire about alternative therapy use in patients prescribed warfarin.
  • Reporting of documented interactions to regulatory bodies like the FDA's MedWatch program is crucial for pharmacovigilance.