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[Asthma and aspirin intolerance].

E Nizankowska1, A Szczeklik

  • 1Département de Médecine, Université Jagellonne, Krakow, Pologne.

Revue Des Maladies Respiratoires
|July 21, 2000
PubMed
Summary

Aspirin-induced asthma is a specific reaction to non-steroidal anti-inflammatory drugs (NSAIDs). This condition involves airway inflammation due to altered arachidonic acid metabolism, leading to overproduction of cysteinyl leucotrienes.

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Area of Science:

  • Pharmacology
  • Immunology
  • Pulmonology

Context:

  • Adverse drug reactions to NSAIDs present with varied mechanisms.
  • Aspirin-induced asthma is a distinct clinical syndrome characterized by NSAID-triggered asthma.
  • Recent research highlights NSAID interference with arachidonic acid metabolism in the respiratory system.

Purpose:

  • To review aspirin-induced asthma, a specific NSAID adverse reaction.
  • To discuss the pathogenic mechanisms involving arachidonic acid metabolism and cysteinyl leukotriene overproduction.
  • To outline the clinical presentation, pathogenesis, and treatment of aspirin-induced asthma.

Summary:

  • Aspirin-induced asthma is characterized by asthma symptoms triggered by aspirin and NSAIDs.
  • In sensitive individuals, NSAIDs inhibit cyclooxygenase, leading to increased production of cysteinyl leucotrienes in the lungs.
  • This review covers the clinical course, underlying mechanisms, and therapeutic strategies for aspirin-induced asthma.

Impact:

  • Provides a comprehensive overview of aspirin-induced asthma for clinicians and researchers.
  • Enhances understanding of the role of arachidonic acid metabolism in NSAID hypersensitivity.
  • Informs clinical management and treatment approaches for patients with aspirin-induced asthma.

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