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Related Experiment Videos

Cisapride: limited access and alternatives.

J E Richter1

  • 1Department of Gastroenterology, Cleveland Clinic, USA. richtej@ccf.org

Cleveland Clinic Journal of Medicine
|July 21, 2000
PubMed
Summary

Cisapride withdrawal poses challenges for treating nocturnal heartburn, gastroparesis, and dyspepsia. However, alternative treatments are available, and cisapride remains accessible via a limited-access program for specific patients.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Cisapride was a commonly prescribed medication for gastrointestinal motility disorders.
  • Its withdrawal from the market creates a therapeutic gap for patients with specific conditions.

Purpose of the Study:

  • To outline the challenges posed by cisapride withdrawal.
  • To identify and discuss alternative treatment options for patients.

Main Methods:

  • Review of existing literature on gastrointestinal motility disorders.
  • Analysis of pharmacological alternatives to cisapride.
  • Examination of the limited-access program for cisapride.

Main Results:

  • Physicians face challenges in managing nocturnal heartburn, gastroparesis, and dyspepsia without cisapride.
  • Several alternative medications and therapeutic strategies are available.
  • Cisapride will remain accessible through a restricted program for refractory cases.

Conclusions:

  • Effective management strategies exist for patients previously treated with cisapride.
  • Alternative therapies should be prioritized, with cisapride reserved for specific, difficult-to-treat cases.

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