Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Minimal-model estimates of insulin sensitivity are insensitive to errors in glucose effectiveness.

C McDonald1, A Dunaif, D T Finegood

  • 1Diabetes Research Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

The Journal of Clinical Endocrinology and Metabolism
|July 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abortion care over 20 weeks gestation: a psychosocial exploration of patient experiences at the Royal Women's Hospital, Victoria, Australia.

Reproductive health·2025
Same author

Clinicians' attitudes towards the undergraduate medical student syllabus in psychiatry.

Irish journal of psychological medicine·2025
Same author

Clinical features of patients who are admitted under different criteria of the Irish Mental Health Act 2001: a retrospective cohort study.

Irish journal of psychological medicine·2025
Same author

The impact of fluphenazine withdrawal: a mirror-image study.

Irish journal of psychological medicine·2024
Same author

Temporal Trends in Severe Brain Injury and Associated Outcomes in Very Preterm Infants.

Neonatology·2024
Same author

A comparison of rate and methods of probable suicide for 2 years pre and post the onset of the COVID-19 pandemic.

Irish journal of psychological medicine·2024
Same journal

Continuous glucose monitoring-derived time in range is associated with changes in arterial stiffness in type 2 diabetes.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes.

The Journal of clinical endocrinology and metabolism·2026
Same journal

From Premature Adrenarche to Adult Metabolic Risk and Hyperandrogenism: A Systematic Review and Meta-Analysis.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Open-Label 9-Year Follow-Up Extension Phase 2 Study of Once-Weekly Somatrogon in Children With Growth Hormone Deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Correction to: "CAHQL: A Patient-Reported Outcome Instrument to Assess Health-Related Quality of Life in Congenital Adrenal Hyperplasia".

The Journal of clinical endocrinology and metabolism·2026
Same journal

Approach to Personalizing the Treatment of Osteoporosis.

The Journal of clinical endocrinology and metabolism·2026
See all related articles

The minimal-model accurately estimates insulin sensitivity (S(I)) despite potential overestimations in glucose effectiveness (S(G)). Adjusting S(G) did not significantly impact S(I) calculations in this study.

Area of Science:

  • Metabolic research
  • Physiological modeling
  • Endocrinology

Background:

  • The minimal-model estimates insulin sensitivity (S(I)) and glucose effectiveness (S(G)) from glucose and insulin dynamics.
  • Previous work indicated minimal-model overestimates S(G) in individuals with normal insulin secretion.

Purpose of the Study:

  • To investigate if overestimation of S(G) affects the estimation of S(I) using the minimal-model.
  • To determine the independence of S(I) estimation from S(G) accuracy.

Main Methods:

  • Analysis of 56 glucose tolerance tests from women of varying weight and PCOS status.
  • Constraining the glucose effectiveness (S(G)) parameter in the minimal-model to lower values.
  • Examining the impact on the insulin sensitivity index (S(I)) estimation.

Related Experiment Videos

Main Results:

  • Constraining S(G) led to significant increases in other model parameters (P2, P3).
  • Despite substantial S(G) constraint (down to 40% of unconstrained value), S(I) decreased by only 3%.
  • Insulin sensitivity index (S(I)) remained largely unaffected by S(G) value adjustments.

Conclusions:

  • Minimal-model-derived insulin sensitivity (S(I)) estimation is robust and independent of potential errors in glucose effectiveness (S(G)) calculations.
  • The findings support the reliability of S(I) derived from the minimal-model, even with imperfect S(G) values.