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Posterior uveitis and primary cerebral reticulum cell sarcoma.

R E Appen

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |February 1, 1975
    PubMed
    Summary

    Primary cerebral reticulum cell sarcoma can manifest as posterior uveitis. However, a review of 19 cases did not confirm a high incidence of ocular involvement, suggesting posterior uveitis warrants investigation for this rare brain tumor.

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    Area of Science:

    • Ophthalmology
    • Neurology
    • Oncology

    Background:

    • Primary cerebral reticulum cell sarcoma (a type of non-Hodgkin lymphoma) can present with neurological symptoms.
    • Ocular involvement, specifically posterior uveitis, has been anecdotally linked to this rare brain tumor.

    Purpose of the Study:

    • To evaluate the incidence of ocular involvement in patients diagnosed with primary cerebral reticulum cell sarcoma.
    • To determine if posterior uveitis is a reliable early indicator of cerebral reticulum cell sarcoma.

    Main Methods:

    • Retrospective review of 19 patient cases diagnosed with primary cerebral reticulum cell sarcoma at Massachusetts General Hospital.
    • Analysis of clinical records for documented ocular symptoms, particularly posterior uveitis.

    Main Results:

    • The study did not confirm a previously reported high incidence of ocular involvement in patients with cerebral reticulum cell sarcoma.
    • Posterior uveitis was observed, but not consistently linked to a definite cerebral mass at presentation.

    Conclusions:

    • While unexplained posterior uveitis can be a presenting sign, it is not a universally high-incidence finding in cerebral reticulum cell sarcoma.
    • The presence of posterior uveitis, especially when remote from a known cerebral mass, should prompt consideration of primary cerebral reticulum cell sarcoma in the differential diagnosis.

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