Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Review: low caloric intake and gall-bladder motor function.

D Festi1, A Colecchia, A Larocca

  • 1Department of Medicine and Aging, University G. d'Annunzio, St Annunziata Hospital, Chieti, Italy. dfesti@unich.it

Alimentary Pharmacology & Therapeutics
|July 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro cytotoxic mechanisms of Pt(O,O'-acac)(γ-acac)(DMS): mitochondrial dysfunction and impaired autophagy in U251 cell line.

Cell death discovery·2026
Same author

Prevalence of sacroiliitis on magnetic resonance enterography in Crohn's disease and its association with intestinal findings: a monocentric observational cross-sectional study.

Clinical and experimental medicine·2025
Same author

Circulating myomiRNAs as biomarkers in patients with Cushing's syndrome.

Journal of endocrinological investigation·2023
Same author

The management of endoscopic retrograde cholangio- pancreatography-related infections risk: results of an italian survey at regional level.

Annali di igiene : medicina preventiva e di comunita·2022
Same author

Prevalence and risk factors for acute stress disorder in female victims of sexual assault.

Psychiatry research·2021
Same author

Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes.

Diabetes & metabolism·2019

Very low-calorie diets (VLCD) increase gallstone risk by affecting gallbladder motility and bile saturation. Maintaining adequate dietary fat content during VLCD may prevent gallstone formation by promoting gallbladder emptying.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Bariatric Medicine

Background:

  • Cholelithiasis (gallstones) is a significant hepatobiliary manifestation of obesity.
  • Obesity increases gallstone risk due to elevated cholesterol saturation in gallbladder bile.
  • Gallstone incidence rises during weight reduction with very low-calorie diets (VLCD).

Purpose of the Study:

  • Investigate the mechanisms of gallstone formation during VLCD.
  • Evaluate the role of gallbladder motility in VLCD-induced gallstone development.
  • Assess the impact of dietary fat content on gallbladder function during VLCD.

Main Methods:

  • Review of pathogenetic mechanisms for gallstone formation during VLCD.
  • Analysis of studies on gallbladder motility during rapid weight loss.

Related Experiment Videos

  • Examination of gallbladder emptying responses to varying meal fat content before and during VLCD.

    • Main Results:

    • VLCD can lead to gallbladder stasis due to reduced stimulation from low-fat content.
    • A minimum of 10g fat is required for effective gallbladder emptying.
    • Gallbladder emptying is reduced with low-fat meals compared to higher-fat meals, both before and during VLCD.

    Conclusions:

    • Gallbladder motility alterations during VLCD contribute to gallstone formation.
    • Adequate dietary fat content in VLCD may prevent gallstones by maintaining gallbladder motility.
    • Modifying VLCD fat content is a potentially more economical and physiological approach than pharmacological agents like ursodeoxycholic acid.